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Current Cardiology Reviews


ISSN (Print): 1573-403X
ISSN (Online): 1875-6557

The Pathophysiology of Uric Acid in Relation to Cardiovascular Disease

Author(s): Matiullah Naqibullah, Maiken J. Calberg and Erik Kjoller

Volume 3, Issue 2, 2007

Page: [99 - 103] Pages: 5

DOI: 10.2174/157340307780618406

Price: $65


Uric acid is produced by the degradation of purines, a process catalysed by xanthine oxidase, which is also responsible for the production of toxic free radicals. This provides a central link to the association between serum uric acid and myocardial ischemia, myocardial dysfunction and also non-cardiac dysfunction in patients with heart disease, mainly due to an impaired peripheral circulation. Uric acid can thus be considered a marker for pathophysiological mechanisms in patients with heart disease, and thus an explanation for S-uric acids prognostic importance. Inhibition of xanthine oxidase by allopurinol may possibly be used as a therapy for patients with heart disease in the future.

Keywords: Uric acid, xanthine dehydrogenase, cardiovascular disease, myocardial ischemia, endothelium, heart failure, ventricular dysfunction, allopurinol, metabolism, pathophysiological mechanism

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