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Current Inorganic Chemistry (Discontinued)

Editor-in-Chief

ISSN (Print): 1877-9441
ISSN (Online): 1877-945X

Cation-Responsive MRI Contrast Agents Based on Gadolinium(III)

Author(s): Goran Angelovski and Ilgar Mamedov

Volume 1 , Issue 1 , 2011

Page: [76 - 90] Pages: 15

DOI: 10.2174/1877944111101010076

Abstract

Magnetic resonance imaging (MRI) offers the ability to visualize a number of biological processes at the molecular and cellular level. The quest for MRI methods that enable the monitoring of these processes with improved specificity and spatiotemporal resolution has induced a considerable amount of research into the chemistry of contrast agents. A novel class of agents has been developed that is able to report a change in its magnetic properties as a function of a specific parameter in the surrounding microenvironment. The vast majority consist of paramagnetic Gd3+ complexes that enhance the contrast in the MR image upon a change in the local concentration of a biologically relevant ion, such as H+, Ca2+, Zn2+, or Cu2+. This review summarizes their coordination chemistry and further aspects of these responsive paramagnetic complexes and discusses the most recent examples that are described in the literature.

Keywords: Biologically active cations, gadolinium, lanthanide complexes, longitudinal relaxivity, magnetic resonance imaging, metal-ion chelators, responsive contrast agents, Ligands, Relaxivity, Contrast Agents


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