Abstract
It is well established that major psychosis (schizophrenia and bipolar disorder) has a strong hereditary basis. However, no unequivocal genetic mutation or polymorphism underlying these disorders has been identified thus far. This paper discusses the role of epigenetics (heritable changes in gene expression not involving changes in DNA sequence) in the pathogenesis of the major psychoses. Importantly, epigenetics offers a conceptual interface between the environment and the genome in the pathogenesis of these disorders. The paper discusses the epigenetically modified genes that are thought to predispose to the development of the major psychoses. The putative environmental factors that can epigenetically modify the genes underlying these disorders are also presented. Finally, the paper offers a framework for epigenetics research applications with considerations over diagnosis, treatment, and prevention of these disorders that have a substantial public health burden throughout the world including the Asia-Pacific region.
Keywords: Disease risk, epigenetics, epigenome, methylation, personalized medicine, psychiatry, psychosis, variability
Current Pharmacogenomics and Personalized Medicine
Title: Epigenetic Basis of Individual Variability to Major Psychosis
Volume: 8 Issue: 3
Author(s): Jacob Peedicayil
Affiliation:
Keywords: Disease risk, epigenetics, epigenome, methylation, personalized medicine, psychiatry, psychosis, variability
Abstract: It is well established that major psychosis (schizophrenia and bipolar disorder) has a strong hereditary basis. However, no unequivocal genetic mutation or polymorphism underlying these disorders has been identified thus far. This paper discusses the role of epigenetics (heritable changes in gene expression not involving changes in DNA sequence) in the pathogenesis of the major psychoses. Importantly, epigenetics offers a conceptual interface between the environment and the genome in the pathogenesis of these disorders. The paper discusses the epigenetically modified genes that are thought to predispose to the development of the major psychoses. The putative environmental factors that can epigenetically modify the genes underlying these disorders are also presented. Finally, the paper offers a framework for epigenetics research applications with considerations over diagnosis, treatment, and prevention of these disorders that have a substantial public health burden throughout the world including the Asia-Pacific region.
Export Options
About this article
Cite this article as:
Peedicayil Jacob, Epigenetic Basis of Individual Variability to Major Psychosis, Current Pharmacogenomics and Personalized Medicine 2010; 8 (3) . https://dx.doi.org/10.2174/187569210792246290
DOI https://dx.doi.org/10.2174/187569210792246290 |
Print ISSN 1875-6921 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6913 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Editorial (Thematic Issue: Pharmacologic Strategies with Afterload Reduction in Low Cardiac Output Syndrome After Pediatric Cardiac Surgery)
Current Vascular Pharmacology Adrenomedullin: Exciting New Horizons
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Volatile Disease Biomarkers in Breath: A Critique
Current Pharmaceutical Biotechnology A Micro-Aggregation Algorithm Based on Density Partition Method for Anonymizing Biomedical Data
Current Bioinformatics Carotid Endarterectomy and Carotid Artery Stenting Lead to Improved Cognitive Performance in Patients with Severe Carotid Artery Stenosis
Current Neurovascular Research The Association between Metabolic Syndrome and Serum Levels of Adiponectin and High Sensitive C Reactive Protein in Gorgan
Endocrine, Metabolic & Immune Disorders - Drug Targets How to Make a Non-Antigenic Protein (Auto) Antigenic: Molecular Complementarity Alters Antigen Processing and Activates Adaptive-Innate Immunity Synergy
Anti-Cancer Agents in Medicinal Chemistry Adverse Effects of Cigarette Smoke and Induction of Oxidative Stress in Cardiomyocytes and Vascular Endothelium
Current Pharmaceutical Design Synthetic Thioamide, Benzimidazole, Quinolone and Derivatives with Carboxylic Acid and Ester Moieties: A Strategy in the Design of Antituberculosis Agents
Current Medicinal Chemistry microRNAs: Promising Biomarkers and Therapeutic Targets of Acute Myocardial Ischemia
Current Vascular Pharmacology The Role of Endothelial Dysfunction in Aortic Aneurysms
Current Pharmaceutical Design High-Throughput Functional Genomic Methods to Analyze the Effects of Dietary Lipids
Current Pharmaceutical Biotechnology Bariatric Surgery and it Effects on the Respiratory System
Current Respiratory Medicine Reviews Correlation of Urine Biomarkers: Microalbuminuria and Spot Urine Protein among Diabetic Patients. Application of Spot Urine Protein in Diabetic Kidney Disease, Nephropathy, Proteinuria Estimation, Diagnosing and Monitoring
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Discovery Approaches for Novel Dyslipidemia Drugs
Current Drug Discovery Technologies Experimental Benefits of Sex Hormones on Vascular Function and the Outcome of Hormone Therapy in Cardiovascular Disease
Current Cardiology Reviews Evaluation of Endothelial (dys)Function, Left Ventricular Structure and Function in Patients with Chronic Kidney Disease
Current Vascular Pharmacology Prostacyclin Synthase Gene: Implication and Prevention of Cardiovascular Disease
Vascular Disease Prevention (Discontinued) Value of Carnitine Therapy in Kidney Dialysis Patients and Effects on Cardiac Function from Human and Animal Studies
Current Drug Targets Diuretic-Associated Electrolyte Disorders in the Elderly: Risk Factors, Impact, Management and Prevention
Current Drug Safety