Fishing for Age-Related Visual System Mutants: Behavioral Screening of Retinal Degeneration Genes in Zebrafish

Lei      Li; Yuhao      Li; Dongyan      Chen; Jinping      Shao; Xin   le   Li; Chen      Xu

Abstract

The zebrafish (Danio rerio) has recently become a mainstream model system for genetic studies of human diseases, such as neurological degenerative diseases, heart diseases, immuno-system disorders, etc. In this article, we will review some recent findings of the usefulness of zebrafish as a model vertebrate for behavioral screening of mutations in vertebrate visual system, for example, genes involved in age-related retinal degeneration.

Keywords: Neural degeneration, zebrafish, retina, mutation