Abstract
Since the completion of the Human Genome Project, increasing scrutiny has focused on patterns of genetic variation among global populations and their association with disease and human traits. This paper addresses emerging techniques to identify genetic differences, including admixture mapping and the use of ancestry informative markers (AIMS), towards controlling population substructure in genetic association studies. The paper discusses the need to reconcile statistical race used to determine genetic ancestry with phenotypic race in identifying and addressing ongoing health disparities among human populations. As DNA biobanking grows and standards for collecting phenotypic information are developed, clear understanding of the varied approaches to defining race and their implications will be imperative. Central to this explication will be an exploration of how genetic technologies inform current approaches to ancestry and their relevance for pharmacogenomic applications.
Keywords: DNA biobanks, genetic ancestry, health disparities, pharmacogenomics, race-based therapeutics
Current Pharmacogenomics and Personalized Medicine
Title: Defining Statistical Race and Phenotypic Race and Their Implications for Health Disparities
Volume: 7 Issue: 4
Author(s): S. S-J. Lee
Affiliation:
Keywords: DNA biobanks, genetic ancestry, health disparities, pharmacogenomics, race-based therapeutics
Abstract: Since the completion of the Human Genome Project, increasing scrutiny has focused on patterns of genetic variation among global populations and their association with disease and human traits. This paper addresses emerging techniques to identify genetic differences, including admixture mapping and the use of ancestry informative markers (AIMS), towards controlling population substructure in genetic association studies. The paper discusses the need to reconcile statistical race used to determine genetic ancestry with phenotypic race in identifying and addressing ongoing health disparities among human populations. As DNA biobanking grows and standards for collecting phenotypic information are developed, clear understanding of the varied approaches to defining race and their implications will be imperative. Central to this explication will be an exploration of how genetic technologies inform current approaches to ancestry and their relevance for pharmacogenomic applications.
Export Options
About this article
Cite this article as:
Lee S-J. S., Defining Statistical Race and Phenotypic Race and Their Implications for Health Disparities, Current Pharmacogenomics and Personalized Medicine 2009; 7 (4) . https://dx.doi.org/10.2174/187569209790112300
DOI https://dx.doi.org/10.2174/187569209790112300 |
Print ISSN 1875-6921 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6913 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Sarcolemmal K<sub>ATP</sub> Channel Modulators and Cardiac Arrhythmias
Current Medicinal Chemistry Meet Our Editorial Board Member
Cardiovascular & Hematological Disorders-Drug Targets Editorial (Thematic Issue: New Approaches to the Treatment of Alzheimer's Disease)
Current Topics in Medicinal Chemistry Dyslipidemia, Hypertension and Diabetes Metaflammation: A Unique Mechanism for 3 Risk Factors
Current Hypertension Reviews Sleep in Interstitial Lung Disease
Current Respiratory Medicine Reviews Novel Anti-Platelets in Stable Coronary Artery Disease
Current Pharmaceutical Design Thymosin β4 Protein Therapy for Cardiac Repair
Current Pharmaceutical Design Editorial [Hot Topic: Current Hypertension Reviews: Hot Topics Hypertension and Diabetes: An Emphasis on the RAS (Guest Editors: Karin A.M. Jandeleit-Dahm and Terri J. Allen)]
Current Hypertension Reviews RAGE Signaling in Cell Adhesion and Inflammation
Current Pediatric Reviews Imaging Patterns of Cardiovascular Involvement in Mixed Connective Tissue Disease Evaluated by Cardiovascular Magnetic Resonance
Inflammation & Allergy - Drug Targets (Discontinued) The Possible Involvement of HLA Class III Haplotype (RAGE, HSP70 and TNF Genes) in Alzheimer's Disease
Current Alzheimer Research Binding Modes and Pharmacophore Modelling of Thermolysin Inhibitors
Mini-Reviews in Medicinal Chemistry Polypeptide Toxins from Animal Venoms
Recent Patents on DNA & Gene Sequences Pleiotropic Effect of Statins as Antioxidants on Cardiac Hypertrophy
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Thyroid Disorders in Chronic Heart Failure: From Prognostic Set-up to Therapeutic Management
Endocrine, Metabolic & Immune Disorders - Drug Targets Renal Function, Albumin-Creatinine Ratio and Pulse Wave Velocity Predict Silent Coronary Artery Disease and Renal Outcome in Type 2 Diabetic and Prediabetic Subjects
Current Hypertension Reviews Potential Role of Inflammation in Associations between Particulate Matter and Heart Failure
Current Pharmaceutical Design Torasemide in Hypertension and Heart Failure: Re-inventing Loop Diuretic Therapy?
Current Pharmaceutical Design Review of Evidence and Perspectives of Flavonoids on Metabolic Syndrome and Neurodegenerative Disease
Protein & Peptide Letters An Insight Into the Anxiolytic Effects of Lignans (Phyllanthin and Hypophyllanthin) and Tannin (Corilagin) Rich Extracts of <i>Phyllanthus amarus</i> : An <i>In-Silico</i> and <i>In-vivo</i> approaches
Combinatorial Chemistry & High Throughput Screening