Implications of RNA Helicases in HIV-1 Replication: Possible Roles in Latency

Title: Implications of RNA Helicases in HIV-1 Replication: Possible Roles in Latency

Volume: 9 Issue: 8

Author(s): Lara Ajamian and Andrew J. Mouland

Affiliation:

Keywords: AIDS, HIV-1, integration, latency, Rev, RNA helicases, RNA export, Tat, Viral Genomic, RNA, Viral Genomic RNA

Abstract: HAART treatment has greatly improved life expectancy of HIV-1-infected individuals. Unfortunately, latency still remains the major barrier towards HIV-1 eradication. Efforts to identify viral and host cell proteins involved in latency remain important research areas to win this war against HIV-1. Here, we review the contributions of several factors in the establishment of latently infected cells. In addition, we also raise the possibility that RNA helicases, while playing important roles at almost every step of the HIV-1 replication cycle, could be implicated in the processes governing the establishment of these latent reservoirs.

Cite this article as:

Ajamian Lara and J. Mouland Andrew, Implications of RNA Helicases in HIV-1 Replication: Possible Roles in Latency, Current HIV Research 2011; 9 (8) . https://dx.doi.org/10.2174/157016211798998835