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Current Drug Discovery Technologies


ISSN (Print): 1570-1638
ISSN (Online): 1875-6220

Physicochemical Properties of pDNA/Chitosan Complexes as Gene Delivery Systems

Author(s): Kenji Hagiwara, Riany Anastasia, Mitsuhiro Nakata and Toshinori Sato

Volume 8, Issue 4, 2011

Page: [329 - 339] Pages: 11

DOI: 10.2174/157016311798109362

Price: $65


Successful gene therapy depends on the development of effective gene carriers. Naturally occurring chitosan has been employed widely as a non-viral gene carrier because of its low toxicity, low immunogenicity, biocompatibility, and biodegradability. In this review, we summarize the utilization of chitosan, modified chitosan, and chitosan-containing ternary complexes as gene carriers. In particular, we discuss the influence of the physicochemical features of pDNA/chitosan complexes on their functions, such as stability and gene transfer into cells.

Keywords: Chitosan, sugar-modified chitosan, DNA complex, gene delivery system, cell transfection, morphology, atomic force microscopy, intracellular trafficking, electrostatic, zeta potential

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