D-tagatose is a natural monosaccharide with a low caloric value and has an anti-hyperglycemiant effect. This hexose has potential applications both in pharmaceutical and agro-food industries. However, the use of D-tagatose remains limited by its production cost. Many production procedures including chemical and biological processes were developed and patented. The most profitable production way is based on the use of L-arabinose isomerase which allows the manufacture of D-tagatose with an attractive rate. Future developments are focused on the generation of L-arabinose isomerases having biochemical properties satisfying the industrial applications. This report provides a brief review of the most recent patents that have been published relating to this area.
Keywords: L-arabinose isomerase, D-tagatose, biotechnological applications, protein engineering, Bacterial L-Arabinose, Isomerases, sugars, thermophile strains, calorie substrate, anti-biofilm, peripheral blood monocyte cells (PBMCs), hGH-N polypeptides, disulfide bridges, thermophilic arabinose, dimerization, acid-labile subunit