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Current Drug Metabolism


ISSN (Print): 1389-2002
ISSN (Online): 1875-5453

Indoleamine 2,3-Dioxygenase in Hematopoietic Stem Cell Transplantation

Author(s): U. Hainz, B. Jurgens, T. Wekerle, M. G. Seidel and Andreas Heitger

Volume 8, Issue 3, 2007

Page: [267 - 272] Pages: 6

DOI: 10.2174/138920007780362554

Price: $65


Hematopoietic stem cell transplantation (HSCT) is complicated by unwelcome side-effects that arise on the basis of an altered immune system. Infectious complications and alloreactive T-cell responses trigger a process of ongoing immune activation and inflammation. Negative-feedback mechanisms to counteract inflammation involve the induction of the immunoregulatory enzyme indoleamine 2,3-dioxygenase (IDO), which mediates anti-inflammatory activities and T-cell inhibition via tryptophan catabolism. However, persistent immune activation and generalized release of pro-inflammatory cytokines deviate immune regulation towards chronic suppression incapable to abrogate the inflammatory response. This review focuses on the unique role of tryptophan catabolism in modulating inflammatory processes and T-cell responses after HSCT.

Keywords: Indoleamine 2,3-dioxygenase, HSCT, T-cell, transplantation, tolerance, inflammation, CTLA4, GVHD

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