Fat Tissue Distribution Changes in HIV-Infected Patients Treated with Lopinavir/Ritonavir. Results of the MONARK Trial

Title: Fat Tissue Distribution Changes in HIV-Infected Patients Treated with Lopinavir/Ritonavir. Results of the MONARK Trial

Volume: 9 Issue: 1

Author(s): Sami Kolta, Philippe Flandre, Philippe Ngo Van, Isabelle Cohen-Codar, Marc-Antoine Valantin, Claire Pintado, Philippe Morlat, Francois Boue, Richard Rode, Michael Norton, Brygida Knysz, Karine Briot, Christian Roux and Jean-Francois Delfraissy

Affiliation:

• Clinical Development, Abbott France, B.P. 90233, 94528 Rungis Cedex, France.,France

Keywords: Clinical study, DEXA scans, HIV protease inhibitor, HIV-associated lipodystrophy syndrome, HIV-infection, lopinavir

Abstract: Given the decline in mortality among HIV-infected patients, it has become increasingly important to consider delayed disease-related and/or anti-HIV therapy-related adverse effects, such as lipodystrophy, when choosing initial therapy. Data from the MONARK trial allowed for comparison of the potential lipodystrophic effects of lopinavir/ritonavir (LPV/r) monotherapy with those of triple therapy with LPV/r plus zidovudine (ZDV) and lamivudine (3TC). This was a randomized, open-label, multinational study that included 136 antiretroviral-naive HIV-infected patients. A portion of study patients underwent evaluations of limb and trunk fat tissue by dual-energy x-ray absorptiometry at baseline and after 48 weeks of treatment (and 96 weeks in some patients). Sixty-three patients had paired absorptiometry data at baseline and week 48 (13 patients at week 96). At week 48, median change in limb fat was - 63 g on LPV/r monotherapy versus -703 g on LPV/r + ZDV/3TC triple therapy (p=0.014). The proportion of patients with fat loss ( > 20% loss in limb fat) was significantly lower with LPV/r monotherapy (4.9% versus 27.3%; p=0.018). Changes in trunk fat did not differ significantly between treatments. Nonetheless, limb fat and trunk fat varied in the same direction with both treatments. The decrease in arm lean mass was also significantly less in patients receiving LPV/r monotherapy. Only treatment type emerged as a significant predictor of fat loss (odds ratio, 7.06; 95% CI, 1.11-78.69). These results suggest that LPV/r, and possibly other protease inhibitors, may not be the main contributor to lipoatrophy in HIV-infected patients receiving triple therapy.

Cite this article as:

Kolta Sami, Flandre Philippe, Ngo Van Philippe, Cohen-Codar Isabelle, Valantin Marc-Antoine, Pintado Claire, Morlat Philippe, Boue Francois, Rode Richard, Norton Michael, Knysz Brygida, Briot Karine, Roux Christian and Delfraissy Jean-Francois, Fat Tissue Distribution Changes in HIV-Infected Patients Treated with Lopinavir/Ritonavir. Results of the MONARK Trial, Current HIV Research 2011; 9(1) . https://dx.doi.org/10.2174/157016211794582687