Generic placeholder image

Drug Metabolism Letters

Editor-in-Chief

ISSN (Print): 1872-3128
ISSN (Online): 1874-0758

Morphologic Characterization of PhoenixBio® (uPA+/+/SCID) Humanized Liver Chimeric Mouse Model

Author(s): Richard A. Peterson, David L. Krull, H. Roger Brown and Mark de Serres

Volume 4 , Issue 3 , 2010

Page: [180 - 184] Pages: 5

DOI: 10.2174/187231210791698456

Price: $65

Sekisui-XenoTech-DML
Abstract

Morphological evaluation of humanized chimeric mouse livers from the PhoenixBio® (uPA+/+/SCID) mouse model show robust replacement and expansion with human hepatocytes, however areas of human hepatocytes had prominent steatosis and a variable lack of sinusoids which was consistent with decreased hepatocellular perfusion and lacked bile canalicular formation between human and mouse hepatocytes.

Keywords: Chimeric, drug metabolism, hepatocyte, humanized, liver, mouse


Rights & Permissions Print Export Cite as
© 2022 Bentham Science Publishers | Privacy Policy