Abstract
Alcohol dependence is a major health problem worldwide. Various pharmacological agents have been used in the management of alcohol dependence. This review looks at the role of topiramate and other anticonvulsants in the management of alcohol dependence. Topiramate is the most widely used anticonvulsant in the treatment of alcohol dependence. The literature on topiramate is reviewed and critically analyzed, along with its proposed mechanism of action in alcohol dependence. A review of data available on other anticonvulsants like carbamazepine, oxcarbazepine, sodium valproate, gabapentin and levetiracetam are presented and their potential in the treatment of alcohol dependence is considered, together with future research directions.
Keywords: Topiramate, alcohol dependence, anticonvulsants
CNS & Neurological Disorders - Drug Targets
Title: The Role of Topiramate and Other Anticonvulsants in the Treatment of Alcohol Dependence: A Clinical Review
Volume: 9 Issue: 1
Author(s): Avinash De Sousa
Affiliation:
- Carmel, 18, St. Francis Avenue, Off S.V. Road, Santacruz (West), Mumbai - 400054, State - Maharashtra, India.,India
Keywords: Topiramate, alcohol dependence, anticonvulsants
Abstract: Alcohol dependence is a major health problem worldwide. Various pharmacological agents have been used in the management of alcohol dependence. This review looks at the role of topiramate and other anticonvulsants in the management of alcohol dependence. Topiramate is the most widely used anticonvulsant in the treatment of alcohol dependence. The literature on topiramate is reviewed and critically analyzed, along with its proposed mechanism of action in alcohol dependence. A review of data available on other anticonvulsants like carbamazepine, oxcarbazepine, sodium valproate, gabapentin and levetiracetam are presented and their potential in the treatment of alcohol dependence is considered, together with future research directions.
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Cite this article as:
De Sousa Avinash, The Role of Topiramate and Other Anticonvulsants in the Treatment of Alcohol Dependence: A Clinical Review, CNS & Neurological Disorders - Drug Targets 2010; 9(1) . https://dx.doi.org/10.2174/187152710790966696
DOI https://dx.doi.org/10.2174/187152710790966696 |
Print ISSN 1871-5273 |
Publisher Name Bentham Science Publisher |
Online ISSN 1996-3181 |

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