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Current HIV Research

Editor-in-Chief

ISSN (Print): 1570-162X
ISSN (Online): 1873-4251

Jembrana Disease Virus: Host Responses, Viral Dynamics and Disease Control

Author(s): Moira Desport and Joshua Lewis

Volume 8, Issue 1, 2010

Page: [53 - 65] Pages: 13

DOI: 10.2174/157016210790416370

Price: $65

Abstract

Jembrana disease virus (JDV) is the most recently discovered member of the lentivirus family and causes an acute clinical disease in Bali cattle with a fatality rate of approximately 15%. It is genetically related to bovine immunodeficiency virus (BIV) to the extent that infections cannot yet be differentially diagnosed using serological assays due to cross-reacting epitopes. Despite their close genetic relationship the pathogenesis of JDV infection in Bali cattle is very different to that of BIV in cattle and is unusual for a member of this virus family. The dynamics of JDV replication and clearance during the acute stage of Jembrana disease, the viral tropism, molecular analysis of the viral genome and mRNA transcripts, and the current status of vaccine development and diagnostic assays are all reviewed to provide a greater understanding of the factors that make JDV such an unusual lentivirus.

Keywords: Jembrana disease virus, tropism, viral load, lentivirus, tat, transcription


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