Fatal Lactic Acidosis Precipitated by Nifedipine in a Patient Treated with Disulfiram and Antiretrovirals

Title: Fatal Lactic Acidosis Precipitated by Nifedipine in a Patient Treated with Disulfiram and Antiretrovirals

Volume: 3 Issue: 3

Author(s): Oswald Moling, Giovanni Rimenti, Raffaele Pristera, Claudio Vedovelli, Leonardo Pagani, Greta Spoladore and Peter Mian

Affiliation:

Keywords: Lactic acidosis, nifedipine, disulfiram, amitriptyline, ritonavir, HIV

Abstract: A 43 year old man with HIV and HCV infection and liver cirrhosis developed fatal lactic acidosis within five days from starting nifedipine for arterial hypertension. Multiple drug interactions, current and accumulated drug toxicities and the reduced liver function, might in combination have led to the acute lactic acidosis.

Cite this article as:

Moling Oswald, Rimenti Giovanni, Pristera Raffaele, Vedovelli Claudio, Pagani Leonardo, Spoladore Greta and Mian Peter, Fatal Lactic Acidosis Precipitated by Nifedipine in a Patient Treated with Disulfiram and Antiretrovirals, Drug Metabolism Letters 2009; 3(3) . https://dx.doi.org/10.2174/187231209789352120