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Current HIV Research

Editor-in-Chief

ISSN (Print): 1570-162X
ISSN (Online): 1873-4251

HIV-1 Vpr: A Novel Role in Regulating RNA Splicing

Author(s): Xianfeng Zhang and Yoko Aida

Volume 7, Issue 2, 2009

Page: [163 - 168] Pages: 6

DOI: 10.2174/157016209787581517

Price: $65

Abstract

Pre-mRNA splicing is a critical step in gene expression for metazoans. Several viral proteins regulate the splicing of pre-mRNAs through complex interactions with the host cell RNA splicing machinery. Here, we focus on a novel function of HIV-1 Vpr, which selectively inhibits cellular and viral pre-mRNA splicing via interactions with components of the spliceosome complex. This review discusses our current knowledge of how RNA splicing regulation is accomplished by Vpr-host factor interactions.

Keywords: HIV-1Vpr, splicing inhibition, cellular pre-mRNA, HIV-1 genome, spliceosome


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