Abstract
Pre-mRNA splicing is a critical step in gene expression for metazoans. Several viral proteins regulate the splicing of pre-mRNAs through complex interactions with the host cell RNA splicing machinery. Here, we focus on a novel function of HIV-1 Vpr, which selectively inhibits cellular and viral pre-mRNA splicing via interactions with components of the spliceosome complex. This review discusses our current knowledge of how RNA splicing regulation is accomplished by Vpr-host factor interactions.
Keywords: HIV-1Vpr, splicing inhibition, cellular pre-mRNA, HIV-1 genome, spliceosome
Current HIV Research
Title: HIV-1 Vpr: A Novel Role in Regulating RNA Splicing
Volume: 7 Issue: 2
Author(s): Xianfeng Zhang and Yoko Aida
Affiliation:
Keywords: HIV-1Vpr, splicing inhibition, cellular pre-mRNA, HIV-1 genome, spliceosome
Abstract: Pre-mRNA splicing is a critical step in gene expression for metazoans. Several viral proteins regulate the splicing of pre-mRNAs through complex interactions with the host cell RNA splicing machinery. Here, we focus on a novel function of HIV-1 Vpr, which selectively inhibits cellular and viral pre-mRNA splicing via interactions with components of the spliceosome complex. This review discusses our current knowledge of how RNA splicing regulation is accomplished by Vpr-host factor interactions.
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Cite this article as:
Zhang Xianfeng and Aida Yoko, HIV-1 Vpr: A Novel Role in Regulating RNA Splicing, Current HIV Research 2009; 7 (2) . https://dx.doi.org/10.2174/157016209787581517
DOI https://dx.doi.org/10.2174/157016209787581517 |
Print ISSN 1570-162X |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4251 |
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