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Current HIV Research

Editor-in-Chief

ISSN (Print): 1570-162X
ISSN (Online): 1873-4251

Role of Vpr in HIV-1 Nuclear Import: Therapeutic Implications

Author(s): Yoko Aida and Go Matsuda

Volume 7, Issue 2, 2009

Page: [136 - 143] Pages: 8

DOI: 10.2174/157016209787581418

Price: $65

Abstract

The replication of human immunodeficiency virus type 1 (HIV-1) in non-dividing cells, such as terminally differentiated macrophages, critically depends on the import of the viral pre-integration complex (PIC) into the nucleus. Vpr, one of the accessory gene products of HIV-1, plays a key regulatory role in PIC nuclear import in macrophages, although its role in the PIC entry mechanism remains to be clarified. Here, we summarize what is currently known about the nuclear- entry step of HIV-1 replication, mainly focusing on how Vpr functions as the main regulator of HIV-1 nuclear import and how it could facilitate the development of novel inhibitors of this process.

Keywords: HIV-1Vpr, nuclear import, pre-integration complex (PIC), Importin α, nucleoporins, non-dividing cells, nuclear pore complex (NPC)


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