Abstract
Since the approval of antibodies as therapeutic agents more than 20 years ago, a large about of research conducted by pharmaceutical companies and other institutes has been focused on the development of therapeutic antibodies. Antibody-based drugs have higher specificity and are more effective than chemical reagents in depletion of target cells, particularly diseased cells such as tumor cells, viral-infected cells, and other pathogenic cells. However, as compared to synthetic agents, they are generally more expensive and accelerating expansion of budgets on medicine. Hitherto, genetic engineering techniques, especially molecular display technology, have played an important role in the development of various active therapeutic antibodies. To reduce the expenditure associated with the production of these antibodies, the selection of candidate molecules- an upstream process must be optimized for efficiency. This review article summarizes recent representative patents related to therapeutic antibodies and molecular display techniques that have been used for their production.
Keywords: Therapeutic antibody, molecular display, phage, yeast, affibody, romiplostim, ribosome, monoclonal antibody, Fc domain, TPO
Recent Patents on Biotechnology
Title: Therapeutic Antibodies and Other Proteins Obtained by Molecular Display Technologies
Volume: 3 Issue: 1
Author(s): Seiji Shibasaki and Mitsuyoshi Ueda
Affiliation:
Keywords: Therapeutic antibody, molecular display, phage, yeast, affibody, romiplostim, ribosome, monoclonal antibody, Fc domain, TPO
Abstract: Since the approval of antibodies as therapeutic agents more than 20 years ago, a large about of research conducted by pharmaceutical companies and other institutes has been focused on the development of therapeutic antibodies. Antibody-based drugs have higher specificity and are more effective than chemical reagents in depletion of target cells, particularly diseased cells such as tumor cells, viral-infected cells, and other pathogenic cells. However, as compared to synthetic agents, they are generally more expensive and accelerating expansion of budgets on medicine. Hitherto, genetic engineering techniques, especially molecular display technology, have played an important role in the development of various active therapeutic antibodies. To reduce the expenditure associated with the production of these antibodies, the selection of candidate molecules- an upstream process must be optimized for efficiency. This review article summarizes recent representative patents related to therapeutic antibodies and molecular display techniques that have been used for their production.
Export Options
About this article
Cite this article as:
Shibasaki Seiji and Ueda Mitsuyoshi, Therapeutic Antibodies and Other Proteins Obtained by Molecular Display Technologies, Recent Patents on Biotechnology 2009; 3 (1) . https://dx.doi.org/10.2174/187220809787172641
DOI https://dx.doi.org/10.2174/187220809787172641 |
Print ISSN 1872-2083 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-4012 |
Call for Papers in Thematic Issues
Advancements in Plant Genetics and Genomics
This thematic issue will highlight cutting-edge innovations and recent patents across the breadth of plant genetics and genomics. Key topics will include advanced breeding techniques, omics-based approaches, gene editing, trait discovery, and translational applications for crop improvement. Renowned researchers from leading institutions worldwide will provide state-of-the-art insights and future perspectives ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Chemotherapy Resistance in Breast Cancer
Current Cancer Therapy Reviews The Role of Neuronal Insulin/Insulin-Like Growth Factor-1 Signaling for the Pathogenesis of Alzheimer’s Disease: Possible Therapeutic Implications
CNS & Neurological Disorders - Drug Targets Nanoparticle Therapy for Allergic and Inflammatory Disease
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Nigella sativa and Cancer: A Review Focusing on Breast Cancer, Inhibition of Metastasis and Enhancement of Natural Killer Cell Cytotoxicity
Current Pharmaceutical Biotechnology Cellular Redox Modulator, ortho Mn(III) meso-tetrakis(N-n-Hexylpyridinium-2-yl)porphyrin, MnTnHex-2-PyP5+ in the Treatment of Brain Tumors
Anti-Cancer Agents in Medicinal Chemistry A Network-Based Cancer Drug Discovery: From Integrated Multi-Omics Approaches to Precision Medicine
Current Pharmaceutical Design Another Brick in the Wall: Innate Lymphoid Cells of the Intestine
Current Immunology Reviews (Discontinued) Drug Delivery Systems with Modified Release for Systemic and Biophase Bioavailability
Current Clinical Pharmacology Cutting through the Complexities of mTOR for the Treatment of Stroke
Current Neurovascular Research Pharmacological Drug Delivery Strategies for Improved Therapeutic Effects: Recent Advances
Current Pharmaceutical Design Recent Advances in the Design and Development of Anticancer Molecules based on PROTAC Technology
Current Medicinal Chemistry Melanocortins As Innovative Drugs for Ischemic Diseases and Neurodegenerative Disorders: Established Data and Perspectives
Current Medicinal Chemistry Aptamer-Mediated Polymeric Vehicles for Enhanced Cell-Targeted Drug Delivery
Current Drug Targets TRAIL-Based Therapeutic Approaches for the Treatment of Pediatric Malignancies
Current Medicinal Chemistry Molecular Dynamics Guided Receptor Independent 4D QSAR Studies of Substituted Coumarins as Anticancer Agents
Current Computer-Aided Drug Design The Emerging Roles of Extracellular Vesicles in Ovarian Cancer
Current Drug Metabolism The Place of Somatostatin Analogs in the Diagnosis and Treatment of the Neuoroendocrine Glands Tumors
Recent Patents on Anti-Cancer Drug Discovery Fc Engineering to Improve the Function of Therapeutic Antibodies
Current Pharmaceutical Biotechnology Mechanisms of Corticosteroid Resistance in Severe Asthma and Chronic Obstructive Pulmonary Disease (COPD)
Current Pharmaceutical Design Indoleamine 2,3-dioxygenase as a Modifier of Pathogenic Inflammation in Cancer and other Inflammation-Associated Diseases
Current Medicinal Chemistry