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CNS & Neurological Disorders - Drug Targets

Editor-in-Chief

ISSN (Print): 1871-5273
ISSN (Online): 1996-3181

Alzheimers Disease, Ceramide, Visfatin and NAD

Author(s): James D. Adams Jr.

Volume 7, Issue 6, 2008

Page: [492 - 498] Pages: 7

DOI: 10.2174/187152708787122969

Price: $65

Abstract

This review discusses new mechanisms for the induction of Alzheimers disease, involving lipid toxicity and adipokines. Ceramide induces oxidative stress and the formation of amyloidβ. Visfatin induces oxidative stress, damages the blood brain barrier and increases the attraction of monocytes, neutrophils and other white blood cells. A new mechanism for visfatin/NAD (nicotinamide adenine dinucleotide)-induced oxidative stress is presented involving redox cycling catalyzed by xanthine dehydrogenase and NADH oxidase. These mechanisms are discussed in terms of the treatment of Alzheimers disease.

Keywords: Alzheimer' disease, ceramide, visfatin, NAD, oxidative stress

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