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Current HIV Research

Editor-in-Chief

ISSN (Print): 1570-162X
ISSN (Online): 1873-4251

Cessation of HIV-1 Transcription by Inhibiting Regulatory Protein Rev- Mediated RNA Transport

Author(s): Yuan Cao, Xinyong Liu and Erik De Clercq

Volume 7, Issue 1, 2009

Page: [101 - 108] Pages: 8

DOI: 10.2174/157016209787048564

Price: $65

Abstract

The HIV-1 Rev protein, which traffics through nucleolus and shuttles between nucleus and cytoplasm, facilitates export of unspliced and singly spliced viral transcripts containing RRE RNA by the CRM1 export pathway. Inhibitions of the various stages of Rev-mediated RNA transport can arrest HIV-1 transcriptional process. The current understanding to the mechanism of Rev function, Rev-RRE interaction, as well as inhibitors hereof is reviewed.

Keywords: AIDS, HIV-1, transcription, inhibitors, Rev, RRE, antiviral


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