Cessation of HIV-1 Transcription by Inhibiting Regulatory Protein Rev- Mediated RNA Transport

Title: Cessation of HIV-1 Transcription by Inhibiting Regulatory Protein Rev- Mediated RNA Transport

Volume: 7 Issue: 1

Author(s): Yuan Cao, Xinyong Liu and Erik De Clercq

Affiliation:

Keywords: AIDS, HIV-1, transcription, inhibitors, Rev, RRE, antiviral

Abstract: The HIV-1 Rev protein, which traffics through nucleolus and shuttles between nucleus and cytoplasm, facilitates export of unspliced and singly spliced viral transcripts containing RRE RNA by the CRM1 export pathway. Inhibitions of the various stages of Rev-mediated RNA transport can arrest HIV-1 transcriptional process. The current understanding to the mechanism of Rev function, Rev-RRE interaction, as well as inhibitors hereof is reviewed.

Cite this article as:

Cao Yuan, Liu Xinyong and De Clercq Erik, Cessation of HIV-1 Transcription by Inhibiting Regulatory Protein Rev- Mediated RNA Transport, Current HIV Research 2009; 7(1) . https://dx.doi.org/10.2174/157016209787048564