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Drug Metabolism Letters


ISSN (Print): 1872-3128
ISSN (Online): 1874-0758

Covariates of Amikacin Clearance in Neonates: The Impact of Postnatal Age on Predictability

Author(s): Karel Allegaert, Isabelle Scheers, Veerle Cossey and Brian J. Anderson

Volume 2, Issue 4, 2008

Page: [286 - 289] Pages: 4

DOI: 10.2174/187231208786734157

Price: $65


An earlier reported population pharmacokinetic study documented limited predictability of amikacin clearance (65%) at birth. An exercise in the first month of life resulted in extended predictability (92%) with similar clearance estimates after the first postnatal days, reflecting the impact of postnatal age on clearance predictability.

Keywords: Ontogeny, renal drug clearance, amikacin, covariates, predictability

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