Abstract
We describe the case of a young HIV-positive man on effective HAART with excellent viro-immunological control who presented a massive cardiac infarction. Despite the presence of clinical risk factors for cardiovascular disease, the patient had normal arterial carotid IMT values, known to be strong predictors of atherosclerosis and stroke. Interestingly, parameters of T-cell activation (CD8+CD38+) were shown to increase just before the onset of myocardial infarction. As T-cell activation is known to mediate atherosclerosis, the authors suggest that surrogate immunologic markers should be identified to better assess cardiovascular risk in the setting of HIV infection.
Keywords: Atherosclerosis, cardiovascular risk, HAART, immune activation, intima media thickness
Current HIV Research
Title: Sudden Cardiac Death in a Young HIV-Positive Man on Effective Antiretroviral Therapy
Volume: 6 Issue: 6
Author(s): Camilla Tincati, Dario Bauer, Giusi M. Bellistri, Maddalena Casana, Roberto Ranieri, Teresa Bini, Giulia Marchetti and Antonella Arminio Monforte
Affiliation:
Keywords: Atherosclerosis, cardiovascular risk, HAART, immune activation, intima media thickness
Abstract: We describe the case of a young HIV-positive man on effective HAART with excellent viro-immunological control who presented a massive cardiac infarction. Despite the presence of clinical risk factors for cardiovascular disease, the patient had normal arterial carotid IMT values, known to be strong predictors of atherosclerosis and stroke. Interestingly, parameters of T-cell activation (CD8+CD38+) were shown to increase just before the onset of myocardial infarction. As T-cell activation is known to mediate atherosclerosis, the authors suggest that surrogate immunologic markers should be identified to better assess cardiovascular risk in the setting of HIV infection.
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Tincati Camilla, Bauer Dario, Bellistri M. Giusi, Casana Maddalena, Ranieri Roberto, Bini Teresa, Marchetti Giulia and Monforte Arminio Antonella, Sudden Cardiac Death in a Young HIV-Positive Man on Effective Antiretroviral Therapy, Current HIV Research 2008; 6 (6) . https://dx.doi.org/10.2174/157016208786501517
DOI https://dx.doi.org/10.2174/157016208786501517 |
Print ISSN 1570-162X |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4251 |
Call for Papers in Thematic Issues
Management of HIV: Management of HIV: old challenges and new needs
The aim of this thematic issue is to provide the most recent updates regarding the effective management of HIV infection. Antiretroviral therapy (ART) has significantly decreased HIV-related mortality, leading to an enhancement in the quality of life and life expectancy for people living with HIV (PLWH). Despite the numerous advancements ...read more
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