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Current HIV Research

Editor-in-Chief

ISSN (Print): 1570-162X
ISSN (Online): 1873-4251

HIV Nef: Role in Pathogenesis and Viral Fitness

Author(s): Kevin K. Arien and Bruno Verhasselt

Volume 6, Issue 3, 2008

Page: [200 - 208] Pages: 9

DOI: 10.2174/157016208784325001

Price: $65

Abstract

Conserved in all primate lentivirus genomes, Nef promotes viral replication and infectivity, influences the trafficking of a large number of surface receptors and interferes with TCR signalling, consequently modulating T-cell activation. In vivo observations with Long Term Non-Progressors harbouring a Nef-defective HIV and vaccination studies with Nef-deleted SIV in Rhesus macaques have shown a prominent role for Nef in lentiviral pathogenesis. Here we review the functions of Nef involved in viral replication and infectivity and speculate on a possible role for Nef in HIV fitness.

Keywords: HIV, nef, fitness, pathogenesis, replication


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