Long Term Treatment with Tetradecylthioacetic Acid Improves the Antioxidant Status in Obese Zucker (fa/fa) Rats

Title: Long Term Treatment with Tetradecylthioacetic Acid Improves the Antioxidant Status in Obese Zucker (fa/fa) Rats

Volume: 2 Issue: 2

Author(s): Hege Wergedahl, Kjetil Berge, Pavol Bohov, Karl-Johan Tronstad, Lise Madsen and Rolf K. Berge

Affiliation:

• Institute of Medicine, Section of Medical Biochemistry, University of Bergen, Haukeland University Hospital,N-5021 Bergen, Norway.,Norway

Keywords: Obesity, peroxisome proliferation, antioxidant enzymes, hydrogen peroxide, α-tocopherol, malondialdehyde

Abstract: Increased oxidative stress was observed in obese Zucker rats. Treatment of obese rats with tetradecylthioacetic acid for 12 weeks increased the H2O2-production, but decreased plasma malondialdehyde, changed the serum fatty acid profile, increased liver fatty acid binding protein mRNA, and lowered serum insulin, thereby enhancing the antioxidant defense system.

Cite this article as:

Wergedahl Hege, Berge Kjetil, Bohov Pavol, Tronstad Karl-Johan, Madsen Lise and Berge K. Rolf, Long Term Treatment with Tetradecylthioacetic Acid Improves the Antioxidant Status in Obese Zucker (fa/fa) Rats, Drug Metabolism Letters 2008; 2(2) . https://dx.doi.org/10.2174/187231208784041013