Abstract
Increased oxidative stress was observed in obese Zucker rats. Treatment of obese rats with tetradecylthioacetic acid for 12 weeks increased the H2O2-production, but decreased plasma malondialdehyde, changed the serum fatty acid profile, increased liver fatty acid binding protein mRNA, and lowered serum insulin, thereby enhancing the antioxidant defense system.
Keywords: Obesity, peroxisome proliferation, antioxidant enzymes, hydrogen peroxide, α-tocopherol, malondialdehyde
Drug Metabolism Letters
Title: Long Term Treatment with Tetradecylthioacetic Acid Improves the Antioxidant Status in Obese Zucker (fa/fa) Rats
Volume: 2 Issue: 2
Author(s): Hege Wergedahl, Kjetil Berge, Pavol Bohov, Karl-Johan Tronstad, Lise Madsen and Rolf K. Berge
Affiliation:
- Institute of Medicine, Section of Medical Biochemistry, University of Bergen, Haukeland University Hospital,N-5021 Bergen, Norway.,Norway
Keywords: Obesity, peroxisome proliferation, antioxidant enzymes, hydrogen peroxide, α-tocopherol, malondialdehyde
Abstract: Increased oxidative stress was observed in obese Zucker rats. Treatment of obese rats with tetradecylthioacetic acid for 12 weeks increased the H2O2-production, but decreased plasma malondialdehyde, changed the serum fatty acid profile, increased liver fatty acid binding protein mRNA, and lowered serum insulin, thereby enhancing the antioxidant defense system.
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Cite this article as:
Wergedahl Hege, Berge Kjetil, Bohov Pavol, Tronstad Karl-Johan, Madsen Lise and Berge K. Rolf, Long Term Treatment with Tetradecylthioacetic Acid Improves the Antioxidant Status in Obese Zucker (fa/fa) Rats, Drug Metabolism Letters 2008; 2(2) . https://dx.doi.org/10.2174/187231208784041013
DOI https://dx.doi.org/10.2174/187231208784041013 |
Print ISSN 1872-3128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1874-0758 |

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