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Drug Metabolism Letters

Editor-in-Chief

ISSN (Print): 1872-3128
ISSN (Online): 1874-0758

Endothelial Cell-Based Methods for the Detection of Cyanobacterial Anti- Inflammatory and Wound-Healing Promoting Metabolites

Author(s): Christoph Wiesner, Jiri Kopecky, Maren Pflueger, Harald Hundsberger, Barbara Entler, Christoph Kleber, Josef Atzler, Pavel Hrouzek, Dalibor Stys, Alena Lukesova, Wolfgang Schuett and Rudolf Lucas

Volume 1 , Issue 4 , 2007

Page: [254 - 260] Pages: 7

DOI: 10.2174/187231207783221385

Price: $65

Abstract

Acute lung injury is accompanied by an increased endothelial chemokine production and adhesion molecule expression, which may result in an extensive neutrophil infiltration. Moreover, a destruction of the alveolar epithelium and capillary endothelium may result in permeability edema. As such, the search for novel anti-inflammatory substances, able to downregulate these parameters as well as the tissue damage holds therapeutic promise. We therefore describe here the use of human endothelial cell-based in vitro assays for the detection of anti-inflammatory and wound-healing metabolites from cyanobacteria.

Keywords: Nostoc, ARDS, endothelium, ICAM-1, Interleukin 8, wound-healing


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