Abstract
Human immunodeficiency virus has evolved several redundant mechanisms to remove its receptor, the CD4 molecule, from the cell surface. Indeed, HIV-1 encodes three proteins, Nef, Vpu and Env, that have a profound effect on CD4 trafficking and catabolism. Given this functional convergence, it is believed that cell surface CD4 regulation constitutes an important determinant of viral replication and pathogenesis in vivo. This review highlights recent progress made in our understanding of the molecular mechanisms underlying the down-regulation of the CD4 receptor by HIV-1 and describes our current comprehension of the role of CD4 down-regulation during HIV-1 infection.
Keywords: hiv-1, cd4 down-regulation, nef, env, vpu, replication, pathogenesis
Current HIV Research
Title: Role of CD4 Receptor Down-regulation During HIV-1 Infection
Volume: 2 Issue: 1
Author(s): Karine Levesque, Andres Finzi, Julie Binette and Eric A. Cohen
Affiliation:
Keywords: hiv-1, cd4 down-regulation, nef, env, vpu, replication, pathogenesis
Abstract: Human immunodeficiency virus has evolved several redundant mechanisms to remove its receptor, the CD4 molecule, from the cell surface. Indeed, HIV-1 encodes three proteins, Nef, Vpu and Env, that have a profound effect on CD4 trafficking and catabolism. Given this functional convergence, it is believed that cell surface CD4 regulation constitutes an important determinant of viral replication and pathogenesis in vivo. This review highlights recent progress made in our understanding of the molecular mechanisms underlying the down-regulation of the CD4 receptor by HIV-1 and describes our current comprehension of the role of CD4 down-regulation during HIV-1 infection.
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Cite this article as:
Levesque Karine, Finzi Andres, Binette Julie and Cohen A. Eric, Role of CD4 Receptor Down-regulation During HIV-1 Infection, Current HIV Research 2004; 2 (1) . https://dx.doi.org/10.2174/1570162043485086
DOI https://dx.doi.org/10.2174/1570162043485086 |
Print ISSN 1570-162X |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4251 |
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