Abstract
Much attention has been focused on CD4+ memory / primed T cells and monocytes / macrophages as the predominant targets of HIV infection. Considerable evidence, however, indicates that cell types that are classically not permissive to HIV infection, can be a potent source of productive virus replication in response to immune modulation. This immune modulation can be in the form of cytokine stimulation pre- or postinfection or by activating these “non-conventional” targets. In this review, we will provide evidence for immune modulation of HIV infection with special emphasis on immune modulation of HIV replication in classically non-HIV permissive primary cells of both lymphoid and non-lymphoid origins. We will also examine the impact of HIV infection of these non-conventional targets as they pertain to both HIV immunoand neuro-pathogenesis.
Keywords: immune reconstitution, cytokine therapy, hiv, neuropathogenesis
Current HIV Research
Title: Immune Modulation of HIV Replication: Relevance to HIV Immuno- and Neuro-Pathogenesis
Volume: 2 Issue: 4
Author(s): Elizabeth Z. Managlia, Deborah Carroll, Andrew Zloza and Lena Al-Harthi
Affiliation:
Keywords: immune reconstitution, cytokine therapy, hiv, neuropathogenesis
Abstract: Much attention has been focused on CD4+ memory / primed T cells and monocytes / macrophages as the predominant targets of HIV infection. Considerable evidence, however, indicates that cell types that are classically not permissive to HIV infection, can be a potent source of productive virus replication in response to immune modulation. This immune modulation can be in the form of cytokine stimulation pre- or postinfection or by activating these “non-conventional” targets. In this review, we will provide evidence for immune modulation of HIV infection with special emphasis on immune modulation of HIV replication in classically non-HIV permissive primary cells of both lymphoid and non-lymphoid origins. We will also examine the impact of HIV infection of these non-conventional targets as they pertain to both HIV immunoand neuro-pathogenesis.
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Cite this article as:
Managlia Z. Elizabeth, Carroll Deborah, Zloza Andrew and Al-Harthi Lena, Immune Modulation of HIV Replication: Relevance to HIV Immuno- and Neuro-Pathogenesis, Current HIV Research 2004; 2 (4) . https://dx.doi.org/10.2174/1570162043351020
DOI https://dx.doi.org/10.2174/1570162043351020 |
Print ISSN 1570-162X |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4251 |
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Management of HIV: Management of HIV: old challenges and new needs
The aim of this thematic issue is to provide the most recent updates regarding the effective management of HIV infection. Antiretroviral therapy (ART) has significantly decreased HIV-related mortality, leading to an enhancement in the quality of life and life expectancy for people living with HIV (PLWH). Despite the numerous advancements ...read more
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