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Current Drug Targets - CNS & Neurological Disorders

Editor-in-Chief

ISSN (Print): 1568-007X
ISSN (Online): 1568-007X

Abeta Immunotherapy and Other Means to Remove Amyloid

Author(s): Edith G. McGeer and Patrick L. McGeer

Volume 4 , Issue 5 , 2005

Page: [569 - 573] Pages: 5

DOI: 10.2174/156800705774322067

Price: $65

Abstract

The amyloid cascade hypothesis postulates that accumulation of beta-amyloid (Abeta) plays a key role in the development of Alzheimers disease (AD). Accordingly, much effort has gone into reducing the amyloid burden, especially in transgenic mice expressing mutations in human amyloid precursor protein. Such mice develop amyloid plaques but not neurofibrillary tangles. Immunization with Abeta and other inflammatory stimuli, inhibitors of Abeta formation, cholesterol lowering agents, beta-sheet breaker peptides, antioxidants and various miscellaneous agents have been found to reduce the more soluble Abeta in such transgenic mice. Whether they would affect the more consolidated, cross-linked Abeta of AD and, if they did, whether that would really prove an effective treatment for the disease remains for future research to determine.

Keywords: alzheimers disease, amyloid precursor protein, presenilin, immunotherapy, nsaids, beta-secretase, antioxidants, apolipoprotein


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