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Current Drug Targets - CNS & Neurological Disorders

Editor-in-Chief

ISSN (Print): 1568-007X
ISSN (Online): 1568-007X

Neurodegenerative Pathways in Parkinsons Disease: Therapeutic Strategies

Author(s): S. M. Cardoso, P. I. Moreira, P. Agostinho, C. Pereira and C. R. Oliveira

Volume 4 , Issue 4 , 2005

Page: [405 - 419] Pages: 15

DOI: 10.2174/1568007054546072

Price: $65

Abstract

Parkinsons disease (PD), considered one of the major neurological disorders, is characterized by the loss of dopaminergic neurons in the pars compacta of the substantia nigra and by the presence of intraneuronal cytoplasmic inclusions called Lewy bodies. The causes for degeneration of PD neurons remain unclear, however, recent findings contributed to clarify this issue. This review will discuss the current understanding of the mechanisms underlying Parkinsons disease pathogenesis, focusing on the current and potential therapeutic strategies for human treatment.

Keywords: synuclein, neuronal circuits, oxidative stress, mitochondria, proteasome, neuroinflammation, cell death, therapeutics


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