Abstract
We investigated the role of NAT2 on clonazepam acetylation, using transiently expressed human NAT2 alleles. The NAT25*B and the NAT2*6A variant alleles cause a 20 and 22-fold reduction in the Vmax, respectively. We conclude that NAT2 is responsible for 7-aminoclonazepam acetylation and that NAT2 gene polymorphisms impair such metabolic pathway.
Keywords: NAT2, acetylation, polymorphism, pharmacogenomics
Drug Metabolism Letters
Title: Effect of Common NAT2 Variant Alleles in the Acetylation of the Major Clonazepam Metabolite, 7-minoclonazepam
Volume: 1 Issue: 1
Author(s): M. Olivera, C. Martinez, G. Gervasini, J. A. Carrillo, S. Ramos, J. Benitez, E. Garcia-Martin and J. A. G. Agundez
Affiliation:
Keywords: NAT2, acetylation, polymorphism, pharmacogenomics
Abstract: We investigated the role of NAT2 on clonazepam acetylation, using transiently expressed human NAT2 alleles. The NAT25*B and the NAT2*6A variant alleles cause a 20 and 22-fold reduction in the Vmax, respectively. We conclude that NAT2 is responsible for 7-aminoclonazepam acetylation and that NAT2 gene polymorphisms impair such metabolic pathway.
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Cite this article as:
Olivera M., Martinez C., Gervasini G., Carrillo A. J., Ramos S., Benitez J., Garcia-Martin E. and G. Agundez A. J., Effect of Common NAT2 Variant Alleles in the Acetylation of the Major Clonazepam Metabolite, 7-minoclonazepam, Drug Metabolism Letters 2007; 1 (1) . https://dx.doi.org/10.2174/187231207779814283
DOI https://dx.doi.org/10.2174/187231207779814283 |
Print ISSN 1872-3128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1874-0758 |
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