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Letters in Drug Design & Discovery


ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

One Pot Synthesis and In Vitro Antitumor Activity of some Bipyrazolic Tripodal Derivatives

Author(s): Smaail Radi, Yahya Toubi, Nihed Draoui, Olivier Feron and Olivier Riant

Volume 9, Issue 3, 2012

Page: [305 - 309] Pages: 5

DOI: 10.2174/157018012799129792

Price: $65


The synthesis and structure – activity relationships (SAR) antitumor activities of monopyrazolic and bipyrazolic tripodal derivatives are reported here for the first time. The ten products were tested against three human cancer cell lines including breast (MDA-MB231), prostate (PC3) and colorectal (LoVo) cancers. In bipyrazolic series, most of them exhibited a moderate antitumor activity against three human cancer cell lines with an order of 5 > 7 > 8 in case of colorectal cancer and 5 > 7 ≉ 8 in case of breast and prostate cancers.

Keywords: Antitumor activity, Bipyrazoles, LoVo, MDA-MB231, PC3, Synthesis, Pyrazole derivatives, biologically active heterocyclic compounds, bipyrazole-3-carboxylates, Biological Assays, aniline ring, macrocyclic, MTT tests, DMSO, moiety, antitumor activity

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