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Protein & Peptide Letters


ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Molecular Determinants that Convert Hormone Sensitive Lipase into Gibberellin Receptor

Author(s): Ko Hirano, Koichiro Aya, Makoto Matsuoka and Miyako Ueguchi-Tanaka

Volume 19, Issue 2, 2012

Page: [180 - 185] Pages: 6

DOI: 10.2174/092986612799080248

Price: $65


Gibberellins (GAs) are tetracyclic, diterpenoid plant hormones, essential for many developmental processes in higher plants. Plants perceive GA through a nuclear-localized GA receptor, GA INSENSITIVE DWARF1 (GID1). From sequence similarity, it is suggested that GID1 evolved from a hormone-sensitive lipase (HSL), and recent x-ray crystallography of the GA-GID1 complex has given insights into how GID1 recognizes GA. Analyses of the GA signaling pathway in several plant species further suggest that the GID1-mediated GA signaling pathway emerged in the vascular plant lineage and since then regulation of GA recognition specificity seems to have been fine tuned to strictly regulate the on – off GA signal.

Keywords: DELLA protein, gibberellin (GA), GA INSENSITIVE DWARF1 (GID1), hormone-sensitive lipase (HSL), Selaginella moellendorffii, rice, epoxidation, crystallography, Arabidopsis

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