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Protein & Peptide Letters


ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Enzyme Promiscuity in the Hormone-sensitive Lipase Family of Proteins

Author(s): Manco Giuseppe, Merone Luigia, Porzio Elena, Feng Yan and Mandrich Luigi

Volume 19 , Issue 2 , 2012

Page: [144 - 154] Pages: 11

DOI: 10.2174/092986612799080400

Price: $65


The number of enzymes endowed with the capacity to catalyse other reactions than the main, physiological one, a feature that has been called promiscuity, is increasing at a fast pace. Promiscuity is a highly pervasive phenomenon that is present at each level of life complexity. For enzymes, promiscuity encompasses interesting aspects related to their physiological role, evolution and biotechnological applications. Herein, at first we will describe some general aspects of enzyme promiscuity and then we will report some examples from the α/β hydrolase superfamily of proteins, with particular emphasis to the hormone-sensitive lipase family.

Keywords: Promiscuity, α/β hydrolase fold, hormone-sensitive lipase family, biotechnological, conformations, cytochrome P450s, substrate, carboxylesterases, detoxification, ligands

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