Abstract
The initial period of mammalian embryonic development is primarily devoted to cell commitment to the pluripotent lineage, as well as to the formation of extraembryonic tissues essential for embryo survival in utero. This phase of development is also characterized by extensive morphological transitions. Cells within the preimplantation embryo exhibit extraordinary cell plasticity and adaptation in response to experimental manipulation, highlighting the use of a regulative developmental strategy rather than a predetermined one resulting from the non-uniform distribution of maternal information in the cytoplasm. Consequently, early mammalian development represents a useful model to study how the three primary cell lineages; the epiblast, primitive endoderm (also referred to as the hypoblast) and trophoblast, emerge from a totipotent single cell, the zygote. In this review, we will discuss how the isolation and genetic manipulation of murine stem cells representing each of these three lineages has contributed to our understanding of the molecular basis of early developmental events.
Keywords: Blastocyst, mouse development, preimplantation, cell fate, lineage allocation, trophectoderm, epiblast, primitive endoderm, stem cells, ES cell, TS cell, XEN cell, pluripotency
Current Stem Cell Research & Therapy
Title: Troika of the Mouse Blastocyst: Lineage Segregation and Stem Cells
Volume: 7 Issue: 1
Author(s): Jerome Artus and Anna-Katerina Hadjantonakis
Affiliation:
Keywords: Blastocyst, mouse development, preimplantation, cell fate, lineage allocation, trophectoderm, epiblast, primitive endoderm, stem cells, ES cell, TS cell, XEN cell, pluripotency
Abstract: The initial period of mammalian embryonic development is primarily devoted to cell commitment to the pluripotent lineage, as well as to the formation of extraembryonic tissues essential for embryo survival in utero. This phase of development is also characterized by extensive morphological transitions. Cells within the preimplantation embryo exhibit extraordinary cell plasticity and adaptation in response to experimental manipulation, highlighting the use of a regulative developmental strategy rather than a predetermined one resulting from the non-uniform distribution of maternal information in the cytoplasm. Consequently, early mammalian development represents a useful model to study how the three primary cell lineages; the epiblast, primitive endoderm (also referred to as the hypoblast) and trophoblast, emerge from a totipotent single cell, the zygote. In this review, we will discuss how the isolation and genetic manipulation of murine stem cells representing each of these three lineages has contributed to our understanding of the molecular basis of early developmental events.
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Cite this article as:
Artus Jerome and Hadjantonakis Anna-Katerina, Troika of the Mouse Blastocyst: Lineage Segregation and Stem Cells, Current Stem Cell Research & Therapy 2012; 7 (1) . https://dx.doi.org/10.2174/157488812798483403
DOI https://dx.doi.org/10.2174/157488812798483403 |
Print ISSN 1574-888X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3946 |
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