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Protein & Peptide Letters


ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

SCYPPred: A Web-Based Predictor of SNPs for Human Cytochrome P450

Author(s): Li Li, Dong-Qing Wei, Jing-Fang Wang and Kuo-Chen Chou

Volume 19, Issue 1, 2012

Page: [57 - 61] Pages: 5

DOI: 10.2174/092986612798472785

Price: $65


Human cytochrome P450(CYP 450) enzymes mediate over 60% of the phase I-dependent metabolism of clinical drugs. They are also known for the polymorphism functions that have significant impacts on the enzyme activities. In this study, a web-server called SCYPPred was developed for predicting human cytochrome P450 SNPs (Single Nucleotide Polymorphisms) based on the SVM flanking sequence method; SCYPPred can rapidly yield the desired results by using the amino acid sequences information alone. The web-server is accessible to the public at Hopefully SCYPPred could be a useful bioinformatics tool for elucidating the mutation probability of a specific CYP450 enzyme.

Keywords: Cytochrome P450, SNPs, SVM, Mutation Probability, Human cytochrome, SCYPPred, SVM flanking, hemoproteins, archaea, DNA-sequence, Vector encoding, KEGG, RBF, FN, Single Nucleotide Polymorphisms, benchmark dataset

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