Efficient Synthesis of Piperazinediones Using Potassium Iodide Catalysis in Aqueous Media

Title: Efficient Synthesis of Piperazinediones Using Potassium Iodide Catalysis in Aqueous Media

Volume: 8 Issue: 10

Author(s): Yong-Hong Wen, Xiao-Na Chen, Hui-Ling Wen and Xiao-Fang Tang

Affiliation:

Keywords: Chloroacetamide, cyclization reaction, diketopiperazine, piperazinedione, bradykinin, antagonists, agonists, chloroacetamides, acetamide, amino acids

Abstract: A simple and efficient synthetic approach to 1,4-disubstituted piperazine-2,5-diones was developed. A series of symmetrical 1,4-disubstituted piperazine-2,5-diones was prepared from chloroacetamides using potassium iodide catalysis in acetone/water. The structures of two products were confirmed by single crystal X-ray diffraction analysis.

Cite this article as:

Wen Yong-Hong, Chen Xiao-Na, Wen Hui-Ling and Tang Xiao-Fang, Efficient Synthesis of Piperazinediones Using Potassium Iodide Catalysis in Aqueous Media, Letters in Organic Chemistry 2011; 8 (10) . https://dx.doi.org/10.2174/157017811799304098