Preliminary Evaluation of Anticonvulsant Activity of Some Aminoalkanol and Amino Acid Cinnamic Acid Derivatives

Title: Preliminary Evaluation of Anticonvulsant Activity of Some Aminoalkanol and Amino Acid Cinnamic Acid Derivatives

Volume: 9 Issue: 1

Author(s): Agnieszka Gunia, Anna M. Waszkielewicz, Marek Cegla and Henryk Marona

Affiliation:

Keywords: Amino acid derivatives, Aminoalkanol derivatives, Anticonvulsant, MES, ScMet, Synthesis, Cinnamic acid derivatives, trans-cinnamic, aminoalkanol, intaperitoneal, pilocarpine, subcutaneous pentetrazole (ScMet), trans-a-phenylcinnamic, Oxytropis pseudoglandulosa, toluene/K2CO3, acylation, polarimeter

Abstract: A series of aminoalkanol and amino acid derivatives of trans-cinnamic acid as well as aminoalkanol derivatives of α-phenylcinnamic acid was synthesized and evaluated for anticonvulsant activity. All compounds were verified in mice after intraperitoneal (i.p.) administration in maximal electroshock (MES) and subcutaneous pentetrazole (ScMet) induced seizures as well as neurotoxicity assessment. Six of them showed protection in MES at 100 mg/kg b.w. and one at 300 mg/kg b.w. For selected derivatives evaluation in ScMet test in rats after per os (p.o.) administration, 6-Hz test in mice and pilocarpine-induced status in rats were performed. The results are quite encouraging and further modification of the structures might lead to discovering new potential anticonvulsants.

Cite this article as:

Gunia Agnieszka, M. Waszkielewicz Anna, Cegla Marek and Marona Henryk, Preliminary Evaluation of Anticonvulsant Activity of Some Aminoalkanol and Amino Acid Cinnamic Acid Derivatives, Letters in Drug Design & Discovery 2012; 9 (1) . https://dx.doi.org/10.2174/157018012798192982