Abstract
Lung cancer is one of the most common cancers but treatment has limited success and survival rates remain low. The active metabolite of vitamin D, 1,25-dihydroxyvitamin D, has anti-proliferative and pro-apoptotic actions in lung carcinoma cell lines in vitro. Vitamin D deficiency is associated with poor prognosis in lung cancer, and lung cancer survival varies according to vitamin D receptor genotype. Randomized controlled trials should be performed to determine whether vitamin D supplementation might have a role as an adjunct to conventional treatments for lung cancer.
Keywords: Vitamin D, lung cancer, incidence, mortality, chemotherapy, radiotherapy, NSCLC, anti-angiogenic, pro-apoptotic, vitamin D supplementation
Current Respiratory Medicine Reviews
Title: Vitamin D and Lung Cancer
Volume: 7 Issue: 6
Author(s): Helga Rhein
Affiliation:
Keywords: Vitamin D, lung cancer, incidence, mortality, chemotherapy, radiotherapy, NSCLC, anti-angiogenic, pro-apoptotic, vitamin D supplementation
Abstract: Lung cancer is one of the most common cancers but treatment has limited success and survival rates remain low. The active metabolite of vitamin D, 1,25-dihydroxyvitamin D, has anti-proliferative and pro-apoptotic actions in lung carcinoma cell lines in vitro. Vitamin D deficiency is associated with poor prognosis in lung cancer, and lung cancer survival varies according to vitamin D receptor genotype. Randomized controlled trials should be performed to determine whether vitamin D supplementation might have a role as an adjunct to conventional treatments for lung cancer.
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Cite this article as:
Rhein Helga, Vitamin D and Lung Cancer, Current Respiratory Medicine Reviews 2011; 7 (6) . https://dx.doi.org/10.2174/157339811798072649
DOI https://dx.doi.org/10.2174/157339811798072649 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
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