Abstract
The rapid growth of the Protein Data Bank (PDB) highlights a great challenge for researchers to predict the binding sites of protein for specific metal ion(s). Experimental determination of functional features of a protein is expensive, time consuming and difficult to automate. Therefore, there is a great demand of computational methods for predicting functional features of protein. This review sheds light on currently available in-silico methods including different tools and databases which are based on various information of metal ion and their binding sites (protein residue length, amino acid composition, geometrical and molecular information etc.) and determines the efficiency, speed and accuracy by using diverse algorithms which make the tools beneficial.
Keywords: Computational method, Metal binding site, Motif, PDB, Metalloprotein, Stand alone tools, Metal binding Site Predictor, GRID, CHED, MSDsite
Current Bioinformatics
Title: Tools for Predicting Metal Binding Sites in Protein: A Review
Volume: 6 Issue: 4
Author(s): Medhavi Mallick, Ambarish Sharan Vidyarthi and Shankaracharya
Affiliation:
Keywords: Computational method, Metal binding site, Motif, PDB, Metalloprotein, Stand alone tools, Metal binding Site Predictor, GRID, CHED, MSDsite
Abstract: The rapid growth of the Protein Data Bank (PDB) highlights a great challenge for researchers to predict the binding sites of protein for specific metal ion(s). Experimental determination of functional features of a protein is expensive, time consuming and difficult to automate. Therefore, there is a great demand of computational methods for predicting functional features of protein. This review sheds light on currently available in-silico methods including different tools and databases which are based on various information of metal ion and their binding sites (protein residue length, amino acid composition, geometrical and molecular information etc.) and determines the efficiency, speed and accuracy by using diverse algorithms which make the tools beneficial.
Export Options
About this article
Cite this article as:
Mallick Medhavi, Sharan Vidyarthi Ambarish and Shankaracharya , Tools for Predicting Metal Binding Sites in Protein: A Review, Current Bioinformatics 2011; 6 (4) . https://dx.doi.org/10.2174/157489311798072990
DOI https://dx.doi.org/10.2174/157489311798072990 |
Print ISSN 1574-8936 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-392X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The Bioactive Potential of Culturable Fungal Endophytes Isolated From the Leaf of <i>Catharanthus roseus</i> (L.) G. Don
Current Topics in Medicinal Chemistry Pharmacological Approaches Targeting Brain Cell Survival in the Context of Neurodegeneration and Potential Treatment Strategies
Current Neuropharmacology Induced Pluripotent Stem Cells, New Tools for Drug Discovery and New Hope for Stem Cell Therapies
Current Molecular Pharmacology Visualization of Brain Amyloid and Microglial Activation in Mouse Models of Alzheimers Disease
Current Alzheimer Research T Cell Receptor Bias in Humans
Current Immunology Reviews (Discontinued) Serotonin 5-HT6 Receptor Antagonists for the Treatment of Alzheimers Disease
Current Topics in Medicinal Chemistry Induced Pluripotent Stem Cells for the Treatment of Stroke: The Potential and the Pitfalls
Current Stem Cell Research & Therapy Editorial [Hot Topic: Tropical Neurology (Guest Editor: Terezinha C.B. Montelli)]
Central Nervous System Agents in Medicinal Chemistry Classification of Sarcomas Using Bioinformatics and Molecular Profiling
Current Pharmaceutical Biotechnology A Review of Voltammetric Methods for Determination of Dopamine Agonists
Current Analytical Chemistry Importance of Zebrafish as an Efficient Research Model for the Screening of Novel Therapeutics in Neurological Disorders
CNS & Neurological Disorders - Drug Targets The Application of Rational Design on Phospholipase A2 Inhibitors
Current Medicinal Chemistry Current and Future Perspectives on the Major Depressive Disorder: Focus on the New Multimodal Antidepressant Vortioxetine
CNS & Neurological Disorders - Drug Targets Chemistry and Effects of Brainstem Acting Drugs
Central Nervous System Agents in Medicinal Chemistry Proteomic Analysis of Aqueous Humor Proteins Associated with Neovascular Glaucoma Secondary to Proliferative Diabetic Retinopathy
Current Proteomics Editorial
Central Nervous System Agents in Medicinal Chemistry A Novel Dynamic Analysis of Mental Status Linked to Biogenic Amines and Psychopathology
Current Psychiatry Reviews Age-Related Increase in Levels of 5-Hydroxymethylcytosine in Mouse Hippocampus is Prevented by Caloric Restriction
Current Alzheimer Research Application of the O-N Intramolecular Acyl Migration Reaction in Medicinal Chemistry
Current Medicinal Chemistry A Hypothesis for Regenerative Therapy for Neuronal Disease: Stem Cells within Artificial Niche
Current Signal Transduction Therapy