Abstract
Sesquiterpenoids are a group of naturally occurring 15-carbon isoprenoid compounds that are mainly found in higher plants, microorganism and marine life. Many of them provided encouraging leads for chemotherapeutics. In this review, the sesquiterpenoids are classified according to the ring numbering system and the functional groups presented in the core structures as acyclic, mono-, bi-, and tricyclic derivatives, and a current overview of sesquiterpenoids as potential cytotoxic anticancer agents is provided.
Keywords: Anticancer, cancer, cytotoxicity, natural products, sesquiterpenoids, tumor, microorganism, chemotherapeutics, ED50, IC50, EC50, GI50
Mini-Reviews in Medicinal Chemistry
Title: Natural Sesquiterpenoids as Cytotoxic Anticancer Agents
Volume: 11 Issue: 13
Author(s): Q.-F. Chen, Z.-P. Liu and F.-P. Wang
Affiliation:
Keywords: Anticancer, cancer, cytotoxicity, natural products, sesquiterpenoids, tumor, microorganism, chemotherapeutics, ED50, IC50, EC50, GI50
Abstract: Sesquiterpenoids are a group of naturally occurring 15-carbon isoprenoid compounds that are mainly found in higher plants, microorganism and marine life. Many of them provided encouraging leads for chemotherapeutics. In this review, the sesquiterpenoids are classified according to the ring numbering system and the functional groups presented in the core structures as acyclic, mono-, bi-, and tricyclic derivatives, and a current overview of sesquiterpenoids as potential cytotoxic anticancer agents is provided.
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Cite this article as:
Chen Q.-F., Liu Z.-P. and Wang F.-P., Natural Sesquiterpenoids as Cytotoxic Anticancer Agents, Mini-Reviews in Medicinal Chemistry 2011; 11 (13) . https://dx.doi.org/10.2174/138955711797655399
DOI https://dx.doi.org/10.2174/138955711797655399 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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