Abstract
Free radicals (FR) are chemical species of significant importance to biological systems. FRs are generated by endo- as well as exogenous factors. Biological systems are equipped with appropriate metabolic pathways to remove cellular FR as well as repair the damages caused by them. Their cellular/physiological load profoundly influences the metabolism, physiology and overall well being of biological systems. Therefore, they are implicated in cellular degenerative processes and in patho-physiology, including carcinogenesis and ageing. The review shall attempt to give a generalized overview of FR chemistry, especially to the biologically important oxygen free radicals (OFR) and reactive oxygen species (ROS). The review shall also discus the OFR/ROS biology to get an overview of the induced damage at molecular, cellular and organismal levels in order to give a perspective of their influences on the genomic integrity, cellular microenvironment and physiology with special reference to human health.
Keywords: Free radicals, Reactive oxygen species, DNA, Cellular and molecular damage, Diseases, hemolytic cleavage
Mini-Reviews in Organic Chemistry
Title: Oxygen Free Radicals and Their Biomedical Implications: A Mini Review
Volume: 8 Issue: 4
Author(s): R. N. Sharan, M. M. Odyuo and S. Purkayastha
Affiliation:
Keywords: Free radicals, Reactive oxygen species, DNA, Cellular and molecular damage, Diseases, hemolytic cleavage
Abstract: Free radicals (FR) are chemical species of significant importance to biological systems. FRs are generated by endo- as well as exogenous factors. Biological systems are equipped with appropriate metabolic pathways to remove cellular FR as well as repair the damages caused by them. Their cellular/physiological load profoundly influences the metabolism, physiology and overall well being of biological systems. Therefore, they are implicated in cellular degenerative processes and in patho-physiology, including carcinogenesis and ageing. The review shall attempt to give a generalized overview of FR chemistry, especially to the biologically important oxygen free radicals (OFR) and reactive oxygen species (ROS). The review shall also discus the OFR/ROS biology to get an overview of the induced damage at molecular, cellular and organismal levels in order to give a perspective of their influences on the genomic integrity, cellular microenvironment and physiology with special reference to human health.
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N. Sharan R., M. Odyuo M. and Purkayastha S., Oxygen Free Radicals and Their Biomedical Implications: A Mini Review, Mini-Reviews in Organic Chemistry 2011; 8 (4) . https://dx.doi.org/10.2174/157019311797440344
DOI https://dx.doi.org/10.2174/157019311797440344 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
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