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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Synthesis of Some Cyclic Methylene 1,3-Diaza Barbiturates Derivatives

Author(s): Kamal Sweidan, Jorn Engelmann, Rajendra Joshi, Mohammad S. Mubarak and Mustafa M. El-Abadelah

Volume 8, Issue 8, 2011

Page: [603 - 605] Pages: 3

DOI: 10.2174/157017811797249353

Price: $65


The reaction of 1,3-dimethyl-5-bis(thioethyl)methylene barbituric acid (2) with various vic-diamines leads to the formation of the respective 1,3-diazamethylene barbiturate derivatives 3 (a-f) in high yields. Solid-state 13C-NMR, MS and IR spectral data were employed for the characterization of these compounds. Antimicrobial screening revealed that none of the newly synthesized compounds showed appreciable antibacterial activity.

Keywords: 5-bis(thioethyl)methylenebarbiturates, 1,3-diazamethylene barbiturates, 1,3-dimethylbarbituric acid, azaheterocycles, solid-state 13C-NMR, pyrimidine, trioxopyrimidine, nucleophilic, amines, alkylation

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