Facile Microwave-Promoted Knoevenagel Condensation and the Combination of Knoevenagel/ Michael addition Reaction in Aqueous Medium Containing Ionic Surfactant

Mithu      Saha; Jahar      Dey; Kochi      Ismail; Amarta      K. Pal

Abstract

A simple, efficient, environment-friendly and high yielding procedure is developed for the Knoevenagel condensation and the combination of Knoevenagel/ Michael addition reaction of various 1, 3-dicarbonyls and aryl aldehydes in an aqueous surfactant medium. The reaction can be dramatically improved under microwave-irradiation.

Keywords: 4-hydroxy coumarin, barbituric acid, dimedone, Knoevenagel condensation, microwave-irradiation, surfactant medium, Diels-Alder reaction, anti-inflammatory activities, antioxidant, silica gel

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Letters in Organic Chemistry

Title: Facile Microwave-Promoted Knoevenagel Condensation and the Combination of Knoevenagel/ Michael addition Reaction in Aqueous Medium Containing Ionic Surfactant

Volume: 8 Issue: 8

Author(s): Mithu Saha, Jahar Dey, Kochi Ismail and Amarta K. Pal

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Abstract: A simple, efficient, environment-friendly and high yielding procedure is developed for the Knoevenagel condensation and the combination of Knoevenagel/ Michael addition reaction of various 1, 3-dicarbonyls and aryl aldehydes in an aqueous surfactant medium. The reaction can be dramatically improved under microwave-irradiation.

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Saha Mithu, Dey Jahar, Ismail Kochi and K. Pal Amarta, Facile Microwave-Promoted Knoevenagel Condensation and the Combination of Knoevenagel/ Michael addition Reaction in Aqueous Medium Containing Ionic Surfactant, Letters in Organic Chemistry 2011; 8(8) . https://dx.doi.org/10.2174/157017811797249272