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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Facile Microwave-Promoted Knoevenagel Condensation and the Combination of Knoevenagel/ Michael addition Reaction in Aqueous Medium Containing Ionic Surfactant

Author(s): Mithu Saha, Jahar Dey, Kochi Ismail and Amarta K. Pal

Volume 8, Issue 8, 2011

Page: [554 - 558] Pages: 5

DOI: 10.2174/157017811797249272

Price: $65


A simple, efficient, environment-friendly and high yielding procedure is developed for the Knoevenagel condensation and the combination of Knoevenagel/ Michael addition reaction of various 1, 3-dicarbonyls and aryl aldehydes in an aqueous surfactant medium. The reaction can be dramatically improved under microwave-irradiation.

Keywords: 4-hydroxy coumarin, barbituric acid, dimedone, Knoevenagel condensation, microwave-irradiation, surfactant medium, Diels-Alder reaction, anti-inflammatory activities, antioxidant, silica gel

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