Synthesis, Neurotoxicity and Anticonvulsant Study of Some Benzothiazole Analogs

Title: Synthesis, Neurotoxicity and Anticonvulsant Study of Some Benzothiazole Analogs

Volume: 8 Issue: 8

Author(s): Kalyan K. Sethi, Saurabh M. Verma, Naru Prasanthi and Mathrusri M. Annapurna

Affiliation:

Keywords: Benzothiazole sulfonamides, Carbonic Anhydrase Inhibitors, Neurotoxicity, Anticonvulsant, Epilepsy, GABA, antiepileptic drugs AEDs, rotating rod, cancer, acetazolamide (AZA), Anticonvulsant studies, antiglaucoma agents w, Rota rod method

Abstract: A series of benzothiazole sulfonamides, thiosemicarbazones and guanidine derivatives were synthesized by different pathways and tested for the neurotoxicity studies by the Rotarod method. The minimal motor impairment, the significant results were found with compounds (7) and (3). Some of these compounds also showed anticonvulsant activity by decreasing the duration of convulsions in albino mice. Compound (3), (7) and also compound (2) were found to be increased in the onset of convulsion and other test drugs showed moderate protection and animals were recovered in these groups

Cite this article as:

K. Sethi Kalyan, M. Verma Saurabh, Prasanthi Naru and M. Annapurna Mathrusri, Synthesis, Neurotoxicity and Anticonvulsant Study of Some Benzothiazole Analogs, Letters in Drug Design & Discovery 2011; 8 (8) . https://dx.doi.org/10.2174/157018011796575953