Synthesis and Antifungal Activities of Some Aryl Naphthofuran Ketoximes

Title: Synthesis and Antifungal Activities of Some Aryl Naphthofuran Ketoximes

Volume: 8 Issue: 8

Author(s): Ahmet Cagri Karaburun, Nalan Gundogdu-Karaburun, Umit Ucucu and Seref Demirayak

Affiliation:

Keywords: Aryl naphthofuran ketoximes, Aryl naphthofuran O-methylketoximes, Aryl naphthofuran ketoxime acetates, Antifungal activity, Antifungal activities, Candida albicans, Candida glabrata, naphtho[2,1-b]furan-2-yl ketoximes, azole, oxime, diaryl ketoximes, benzofuran-2-yl ketoxime, tetramethylsilane (TMS), Reimer-Tiemann reaction procedure

Abstract: In this study, some aryl naphtho[2,1-b]furan-2-yl ketoximes and their ethers and esters were synthesised. The structure elucidation of the compounds was performed by IR, 1H-NMR and MASS spectroscopic data and elemental analyses results. Antifungal activities of the compounds were tested against Candida albicans (two strains), Candida glabrata, Candida tropicalis and Candida parapsilosis using a microbroth dilution technique. The results showed that the compounds displayed minimum inhibitory concentrations, 7.8-625 µ g/mL.

Cite this article as:

Karaburun Ahmet Cagri, Gundogdu-Karaburun Nalan, Ucucu Umit and Demirayak Seref, Synthesis and Antifungal Activities of Some Aryl Naphthofuran Ketoximes, Letters in Drug Design & Discovery 2011; 8 (8) . https://dx.doi.org/10.2174/157018011796576097