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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Enantioselective Michael Addition of Malonates to Aromatic α,β-Unsaturated Aldehydes Organocatalyzed by (S)-2-[bis(3,4,5-Trifluorophenyl) trimethylsilanyloxymethyl]pyrrolidine

Author(s): Haiwei Ye, Yemin Zheng, Chuanming Yu and Weihui Zhong

Volume 8, Issue 7, 2011

Page: [520 - 525] Pages: 6

DOI: 10.2174/157017811796504927

Price: $65

Abstract

The Michael addition of malonates to aromatic α,β-unsaturated aldehydes was efficiently organocatalyzed by (S)-2-[bis(3,4,5-trifluorophenyl)trimethylsilanyoxymethyl]pyrrolidine, derived from L-proline to afford the corresponding adducts in good yields with good to excellent enantioselectivities.

Keywords: (S)-2-[bis(3,4,5-trifluorophenyl)trimethylsilanyloxymethyl]pyrrolidin, enantioselectivity, Michael addition, organocatalysis, α,β-unsaturated, aldehydes, malonates, L-proline, pyrrolidinemethanol


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