Abstract
Seed proteins that inhibit proteinases are classified in families based on amino acid sequence similarity, nature of reactive site and mechanism of action, and are used as tools for investigating proteinases in physiological and pathological events. More recently, the plant Kunitz family of inhibitors with two disulphide bridges was enlarged with members containing variable number of cysteine residues, ranging from no cysteine at all to more than four residues. The characteristic of these proteins, as well the interactions with their target proteinases, are briefly discussed.
Keywords: Chymotrypsin, kunitz inhibitors, plant inhibitors, primary structure, trypsin inhibitors, Kunitz Proteinase Inhibitors, leguminosae, seed proteins, amino acid sequence, reactive site, actin, disulphide bridges, cysteine residues, proteolysis, MEROPS
Current Protein & Peptide Science
Title: Structural and Functional Properties of Kunitz Proteinase Inhibitors from Leguminosae: A Mini Review
Volume: 12 Issue: 5
Author(s): Maria Luiza Vilela Oliva, Rodrigo da Silva Ferreira, Joana Gasperazzo Ferreira, Claudia Alessandra Andrade de Paula, Carlos E Salas and Misako Uemura Sampaio
Affiliation:
Keywords: Chymotrypsin, kunitz inhibitors, plant inhibitors, primary structure, trypsin inhibitors, Kunitz Proteinase Inhibitors, leguminosae, seed proteins, amino acid sequence, reactive site, actin, disulphide bridges, cysteine residues, proteolysis, MEROPS
Abstract: Seed proteins that inhibit proteinases are classified in families based on amino acid sequence similarity, nature of reactive site and mechanism of action, and are used as tools for investigating proteinases in physiological and pathological events. More recently, the plant Kunitz family of inhibitors with two disulphide bridges was enlarged with members containing variable number of cysteine residues, ranging from no cysteine at all to more than four residues. The characteristic of these proteins, as well the interactions with their target proteinases, are briefly discussed.
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Cite this article as:
Luiza Vilela Oliva Maria, da Silva Ferreira Rodrigo, Gasperazzo Ferreira Joana, Alessandra Andrade de Paula Claudia, E Salas Carlos and Uemura Sampaio Misako, Structural and Functional Properties of Kunitz Proteinase Inhibitors from Leguminosae: A Mini Review, Current Protein & Peptide Science 2011; 12 (5) . https://dx.doi.org/10.2174/138920311796391061
DOI https://dx.doi.org/10.2174/138920311796391061 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
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