Abstract
The management of community-acquired pneumonia remains mainly driven by empiric antibiotic therapy because existing microbiological techniques are relatively insensitive and rarely deliver an answer within a useful time frame. Advances in the molecular detection of Streptococcus pneumoniae in whole blood have been published that suggest that a new era of diagnostics may be ready for routine clinical practice. As well as improved sensitivity over existing culture techniques and a very high specificity, the new assays quantitate the amount of bacteremia which appears to be an extremely useful prognostic marker. Here we review the recent studies and their implications in the setting of pneumococcoal pneumonia.
Keywords: Pneumococcus, PCR, quantitative, bacterial load, Molecular Diagnosis, community-acquired pneumonia, antibiotic therapy, blood, culture techniques, high specificity, alpha-hemolytic, respiratory tract, real-time PCR, DNA
Current Respiratory Medicine Reviews
Title: New Developments in Molecular Diagnosis of Bacteremic Pneumococcal Pneumonia
Volume: 7 Issue: 4
Author(s): Cordelia Kee, Ian Kay and Grant W. Waterer
Affiliation:
Keywords: Pneumococcus, PCR, quantitative, bacterial load, Molecular Diagnosis, community-acquired pneumonia, antibiotic therapy, blood, culture techniques, high specificity, alpha-hemolytic, respiratory tract, real-time PCR, DNA
Abstract: The management of community-acquired pneumonia remains mainly driven by empiric antibiotic therapy because existing microbiological techniques are relatively insensitive and rarely deliver an answer within a useful time frame. Advances in the molecular detection of Streptococcus pneumoniae in whole blood have been published that suggest that a new era of diagnostics may be ready for routine clinical practice. As well as improved sensitivity over existing culture techniques and a very high specificity, the new assays quantitate the amount of bacteremia which appears to be an extremely useful prognostic marker. Here we review the recent studies and their implications in the setting of pneumococcoal pneumonia.
Export Options
About this article
Cite this article as:
Kee Cordelia, Kay Ian and W. Waterer Grant, New Developments in Molecular Diagnosis of Bacteremic Pneumococcal Pneumonia, Current Respiratory Medicine Reviews 2011; 7 (4) . https://dx.doi.org/10.2174/157339811798281269
DOI https://dx.doi.org/10.2174/157339811798281269 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
Call for Papers in Thematic Issues
Exposure to PM2.5 components is associated with respiratory diseases
Through continuous research on the relationship between risk factors and health, it has been found that air pollution, especially atmospheric particulate matter pollution, has become one of the main sources of global disease burden. From 1990 to 2022, the concentration of atmospheric particulate matter pollution has increased by more than ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Bridge Between Neuroimmunity and Traumatic Brain Injury
Current Pharmaceutical Design Carbapenem-Hydrolyzing Gram-Negative Bacteria: Current Options for Treatment and Review of Drugs in Development
Recent Patents on Anti-Infective Drug Discovery Computational Biology Tools for Identifying Specific Ligand Binding Residues for Novel Agrochemical and Drug Design
Current Protein & Peptide Science Structure and Functions of Bacterial Outer Membrane Protein A, A Potential Therapeutic Target for Bacterial Infection
Current Topics in Medicinal Chemistry Colored Representation of Brain Gray Scale MRI Images to Potentially Underscore the Variability and Sensitivity of Images
Current Medical Imaging Is Helicobacter pylori the Infectious Trigger for Headache?: A Review
Infectious Disorders - Drug Targets Pharmacotherpy and Alzheimer’s Disease: The M-Drugs (Melatonin, Minocycline, Modafinil, and Memantine) Approach
Current Pharmaceutical Design Cytochromes P450 in Brain: Function and Significance
Current Drug Metabolism Progress in Drug Treatment of Cerebral Edema
Mini-Reviews in Medicinal Chemistry Role of Resveratrol in Modulating microRNAs in Human Diseases: From Cancer to Inflammatory Disorder
Current Medicinal Chemistry Meningitis Due to Cryptococcus neoformans: Treatment with Posaconazole
Current HIV Research Occipital Encephalocele: Cause, Incidence, Neuroimaging and Surgical Management
Current Pediatric Reviews Impact of Antiretroviral Therapy on the Relapse of Cryptococcosis and Survival of HIV-Infected Patients with Cryptococcal Infection
Current HIV Research Cerebrovascular Complications After Heart Transplantation
Current Cardiology Reviews Honey: The Natural ‟Inhibine”
Anti-Infective Agents QSAR Studies on HSV-1 Inhibitors by CoMFA, CoMSIA and HQSAR Approaches
Letters in Drug Design & Discovery Isolation of the Antibacterial Agent Viridiol from the Mangrove Endophytic Fungus Hypocrea virens, as Monitored by a Biologic Assay Against Escherichia coli and NMR Spectroscopy
Current Biotechnology Mouse ATP-Binding Cassette (ABC) Transporters Conferring Multi-Drug Resistance
Anti-Cancer Agents in Medicinal Chemistry Autoantibodies Associated with Psychiatric Disorders
Current Neurovascular Research Withdrawal Notice: MMR Vaccine Susceptibility of Viral Agents Causing Meningitis and Meningoencephalitis in Children
Infectious Disorders - Drug Targets