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Current Organic Synthesis


ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

Molecular Probes for Bioluminescence Imaging

Author(s): Song Wu, Edwin Chang and Zhen Cheng

Volume 8, Issue 4, 2011

Page: [488 - 497] Pages: 10

DOI: 10.2174/157017911796117188

Price: $65


Bioluminescence refers to the emission of light from a living system in which photoproteins such as luciferase enzymes oxidize their substrates to produce light. Because of its high-sensitivity and low-toxicity, bioluminescence imaging (BLI) is particularly useful for in vitro assays and in vivo small animal imaging. It provides a powerful tool to study various important biological questions and processes including gene and protein expression, protein-protein interactions, protein-nucleic acid interactions, and cell signaling pathway functions. This review highlights some of the latest developments in the design and applications of molecular probes for BLI.

Keywords: Bioluminescence imaging, Molecular Imaging, Probe, Luciferase, Bioluminescence Resonance Energy Transfer, MRI, Luciferase Mutugenesis, D-luciferin Analogs, Luciferase Fused Proteins, Intramolecular Enzyme Complementation

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