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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Synthesis and Biological Activity of Phosphonated Nucleosides: Part 1Furanose, Carbocyclic and Heterocyclic Analogues

Author(s): Anna Piperno, Maria A. Chiacchio, Daniela Iannazzo and Roberto Romeo

Volume 13, Issue 30, 2006

Page: [3675 - 3695] Pages: 21

DOI: 10.2174/092986706779026110

Price: $65

Abstract

Phosphonated nucleosides represent a promising alternative in the improvement of the biological activity of nucleoside analogues in antiviral and anticancer chemotherapy. The basic concept, the chemistry, the different structural modifications and their effects on the antiviral potency will be discussed in this review.

Keywords: Nucleotides, phosphonates, antiviral, nucleosides, anti-herpes, anti-HIV, nucleic acids


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