Abstract
More than fifteen years following the description of Tat as a critical HIV gene expression regulatory protein, additional roles for Tat in HIV replication have been described, including reverse transcription. Tat achieves function through direct interaction with viral proteins, including reverse transcriptase, and numerous cellular proteins including cyclin T1, RNA polymerase II, protein kinase R (PKR), p300/CBP, and P/CAF. Despite our advanced knowledge of how Tat operates, this has not yet resulted in the discovery of effective agents capable of targeting various Tat functions. Nevertheless, Tat remains an attractive, virus-specific molecule and detailed understanding of specific protein interaction holds promise for future drug discovery.
Keywords: HIV-1, Tat, transcription, reverse transcription, trans-activation, acetylation, methylation, phosphorylation
Current Drug Targets
Title: Will Diverse Tat Interactions Lead to Novel Antiretroviral Drug Targets?
Volume: 7 Issue: 12
Author(s): David Harrich, Nigel McMillan, Liliana Munoz, Ann Apolloni and Luke Meredith
Affiliation:
Keywords: HIV-1, Tat, transcription, reverse transcription, trans-activation, acetylation, methylation, phosphorylation
Abstract: More than fifteen years following the description of Tat as a critical HIV gene expression regulatory protein, additional roles for Tat in HIV replication have been described, including reverse transcription. Tat achieves function through direct interaction with viral proteins, including reverse transcriptase, and numerous cellular proteins including cyclin T1, RNA polymerase II, protein kinase R (PKR), p300/CBP, and P/CAF. Despite our advanced knowledge of how Tat operates, this has not yet resulted in the discovery of effective agents capable of targeting various Tat functions. Nevertheless, Tat remains an attractive, virus-specific molecule and detailed understanding of specific protein interaction holds promise for future drug discovery.
Export Options
About this article
Cite this article as:
Harrich David, McMillan Nigel, Munoz Liliana, Apolloni Ann and Meredith Luke, Will Diverse Tat Interactions Lead to Novel Antiretroviral Drug Targets?, Current Drug Targets 2006; 7 (12) . https://dx.doi.org/10.2174/138945006779025338
DOI https://dx.doi.org/10.2174/138945006779025338 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Call for Papers in Thematic Issues
New drug therapy for eye diseases
Eyesight is one of the most critical senses, accounting for over 80% of our perceptions. Our quality of life might be significantly affected by eye disease, including glaucoma, diabetic retinopathy, dry eye, etc. Although the development of microinvasive ocular surgery reduces surgical complications and improves overall outcomes, medication therapy is ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Preface [ Focus on NeuroAIDS ]
Current HIV Research Alzheimers Disease: Pathological Mechanisms and Recent Insights
Current Neuropharmacology Oestrogen-A Protective Factor in Schizophrenia?
Current Psychiatry Reviews Inflammatory Cytokines, Growth Factors, and Depression
Current Pharmaceutical Design Integrating Care for Older Adults with Cognitive Impairment
Current Alzheimer Research Biomarkers of Alzheimer’s Disease: An Overview of the Recent Inventions
Recent Patents on Biomarkers CEST MRI for Molecular Imaging of Brain Metabolites
Current Molecular Imaging (Discontinued) TRPC Channels and their Implications for Neurological Diseases
CNS & Neurological Disorders - Drug Targets Subject Index To Volume 4
Current HIV Research Patent Selections
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery The Impact of Mitochondrial DNA and Nuclear Genes Related to Mitochondrial Functioning on the Risk of Parkinson’s Disease
Current Genomics 1, 4-Dihydropyridines: A Class of Pharmacologically Important Molecules
Mini-Reviews in Medicinal Chemistry Biochemical Markers for Brain Injury Monitoring in Children with or without Congenital Heart Diseases
CNS & Neurological Disorders - Drug Targets The Role of Blood-Brain Barrier Studies in the Pharmaceutical Industry
Current Drug Metabolism Defects in RNA Metabolism links FTD and ALS Pathogenesis: TDP-43, FUS, and C9orf72
Current Enzyme Inhibition Plant Polyphenols as Neuroprotective Agents in Parkinson’s Disease Targeting Oxidative Stress
Current Drug Targets Dementia After Age 75: Survival in Different Severity Stages and Years of Life Lost
Current Alzheimer Research Neovascular Age-Related Macular Degeneration and its Association with Alzheimer’s Disease
Current Aging Science Potentiality of Oxygen-Ozonetherapy to Improve the Health of Aging People
Current Aging Science Use of Speech Analyses within a Mobile Application for the Assessment of Cognitive Impairment in Elderly People
Current Alzheimer Research